Cardiovascular Medicine and Cardiac Surgery

Aortic abdominal aneurysm is a pathology that has become ever more prevalent and in the event of rupture, have fatal consequences.There are two widely accepted methods of treatment: open surgery (OS) and endovascular repair (EVAR). A combination of both, called a hybrid operation (HO), is useful in dealing with complex aortic morphologies. One of the main risk factors in dealing with complex forms of aortic aneurysm relates to ischaemia/reperfusion. We have, over the past 20 years, accumulated a greater understanding of how to mitigate ischaemia/reperfusion injury. Single-center experience in dealing with reperfusion phenomena will be discussed, and experimental and clinical data will be presented. Experience with some new mediators, in addition to nitric oxide, will be covered. The fundamental role of gasotransmitters will be examined, as will pertinent therapeutic concepts.