Carolina Nunes França has completed her PhD from Federal University of Sao Paulo, Brazil and Post-doctoral studies from University of Bonn, Germany. She is Professor of University of Santo Amaro – UNISA (Health Science Post Graduation), Brazil. She has published more than 36 papers in reputed journals.
Introduction: Chronic kidney disease is characterized by loss, normally gradual and progressive, of the excretory capacity by kidneys and constitutes a serious public health problem and higher rate of cardiovascular events as acute myocardial infarct, stroke and mortality when compared to the general population. Endothelial micro-particles are shed by the membrane of different cell types after activation or apoptosis and are related to classic risk factors and cardiovascular disease. Objective: Evaluate if the progression of kidney disease is related to the increase in circulating endothelial micro-particles, in patients with established cardiovascular disease. Methods: Some variables related to kidney disease (urine and serum creatinine, albumine/creatinine relation, glomerular filtration rate) were correlated with endotelial micro-particle levels, in patients with cardiovascular disease (n=84), comparing the values obtained to micro-particles according to the stage of kidney failure. Results: There were no significant correlations between the parameters evaluated (correlation between endothelial micro-particles and serum creatinine [Spearman, rho = -0,208; p = 0,064]; correlation between endothelial micro-particles and glomerular filtration rate [Spearman, rho = 0.194, p = 0.085]), other correlations also not significant. Conclusion: There was no evidence concerning the increase of endothelial micro-particles related to the progression of kidney disease in patients with cardiovascular disease.
Max and Michael are both medical students in their fourth year, studying at the University of Birmingham. They are both interested in pursuing careers in cardiology and are keen to kick start their research portfolios. This will be their first medical academic conference
Background: PCI is recommended by NICE as an effective intervention in STEMI; however it is not entirely clear whether radial or femoral access is the optimal choice for this procedure. This literature review examines the evidence available and discusses which of the two approaches has the best impact on patient outcomes. Methods: The following review questions were drawn up to focus research: 1. Does radial access carry a reduced risk of vascular complications compared to femoral? 2. What is the difference in mortality between the two approaches? 3. What is the difference in quality of life between the two approaches? 4. Is there a significant reduction in reperfusion time using femoral access compared to radial? A literature search was conducted on the database MEDLINE. Due to the availability of good evidence on MEDLINE, other databases were not used in our literature search. Criteria included English language papers from 2010-2015. A total of 11 studies were included. Discussion: Overall, the studies examined revealed fewer vascular complications and a decreased mortality in patients undergoing PCI via radial access compared to femoral. There were no significant changes in quality of life between the two approaches. There were also no significant differences in reperfusion time. Conclusion: Although femoral has traditionally been the favoured approach for PCI, from the evidence base that across all age groups, it is evident that outcomes are improved using the radial approach. However, there is significant scope for research and innovation to improve techniques for radial access in the future.